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Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome

Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 499-502 doi: 10.1007/s11684-009-0075-9

摘要： The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas, especially for children. A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphoma. Thoracolumbar magnetic resonance imaging (MRI) demonstrated an intraspinal mass. An operation was performed with gross total tumor removal. Histological examination revealed a non-Hodgkin’s B-cell lymphoma. Bone marrow aspiration was negative for lymphoma involvement. No other therapies (chemotherapy and/or radiotherapy) were performed according to the parents’ opinion. The patient died approximately one year after the operation due to brain metastases. The clinical course and imaging features were discussed with a review of literatures.

关键词： non-Hodgkin’     s lymphoma     primary     spinal cord compression syndrome     epidural space    

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Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

《医学前沿（英文）》 2009年 第3卷 第1期   页码 45-48 doi: 10.1007/s11684-009-0019-4

摘要： This study was aimed to explore the anterior cervical surgery methods to treat central cord syndrome without radiographic spinal fracture-dislocation (CCSWORFD), retrospectively analyze the cases of CCSWORFD, and evaluate the curative effect of anterior cervical surgery methods for CCSWORFD. Twenty four cases of CCSWORFD (19 males and 5 females), all suffering from cervical hyperextension injury, between 45-68 (average 59) years old, were operated on by anterior cervical surgery methods. Among these, 18 cases had been followed up for 6-24 (average 15) months; 18 cases, who had anterior decompression and plate fixation with titanium mesh bone grafting or iliac bone grafting achieved reliable effects based on the Japanese Orthopedics Association (JOA) evaluation (improved scores of cases with titanium mesh bone grafting, = 2.800, <0.05; improved scores of cases with iliac bone grafting, = 3.270, <0.05), and reliable reconstruction of cervical spine. The two groups obtained the same curative effect ( = 0.470, >0.05) Most of these cases had degeneration of cervical vertebra. The decompression which relieves the oppression to the spinal cord can help lessen edema of the spinal cord, and early fixation for stability of cervical vertebra is better for the recovery of spinal cord injury. Anterior operation with titanium mesh bone grafting or iliac bone grafting are both reliable curative methods for CCSWORFD, and titanium mesh bone grafting can avoid the trauma of the supplying graft. Mesh bone grafting can also shorten hospital stay.

关键词： central cord syndrome     decompression     surgical     titanium mesh    

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transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinalcord injury

Bin Yu, Xiaosong Gu

《医学前沿（英文）》 2019年 第13卷 第2期   页码 131-137 doi: 10.1007/s11684-018-0642-z

摘要： The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To circumvent these barriers, biomaterial scaffolds are applied to bridge the lesion gaps for the regrowing axons to follow, and, often by combining stem cell transplantation, to enable the local environment in the growth-supportive direction. Manipulations, such as the modulation of PTEN/mTOR pathways, can also enhance intrinsic CNS axon regrowth after injury. Given the complex pathophysiology of SCI, combining biomaterial scaffolds and genetic manipulation may provide synergistic effects and promote maximal axonal regrowth. Future directions will primarily focus on the translatability of these approaches and promote therapeutic avenues toward the functional rehabilitation of patients with SCIs.

关键词： spinal cord injury     biomaterial     extrinsic barrier     intrinsic regeneration capacity    

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Developmental expression of CAPON and Dexras1 in spinal cord of rats

LI Xin, CHENG Chun, CHEN Mengling, GAO Shangfeng, ZHAO Jian, NIU Shuqiong, SHEN Aiguo

《医学前沿（英文）》 2008年 第2卷 第1期   页码 75-81 doi: 10.1007/s11684-008-0014-1

摘要： To study the expression of the carboxy-terminal PSD-95/DLG/ZO-1 ligand of nNOS (CAPON) and Dexras1 mRNA during development in the spinal cord of rats, real-time polymerase chain reaction (Real-time PCR), as a quantitative method, was used to study the developmental expression of CAPON and Dexras1 mRNA level in the spinal cord. The spatial expression of CAPON and Dexras1 mRNA was examined by a combination of hybridization (ISH) and immunofluorescence. During the development of the spinal cord, CAPON mRNA was expressed in low levels from embryo day 14 to day 18. At postnatal day 1, it reached the peak and was expressed in the part which will become the dorsal horn when mature. It then decreased gradually until postnatal week 12, when it presented in the ventral horn. At embryo day 14, Dexras1 mRNA was expressed at low levels, increased during embryo day 16 to day 18 and peaked at postnatal day 1. Spatiotemporal expression of Dexras1 mRNA was similar to CAPON as confirmed by correlation analysis and colocalization. CAPON and neuronal nitric oxide synthase (nNOS) was expressed within the same cells of the dorsal horn at postnatal day 1 but had different subcellular localizations. Co-expression of CAPON and Dexras1 mRNA in myeloid tissue during development process of rat indicates that the adaptor protein, CAPON may play a probable role in differentiation of neurons, synaptic plasticity and synaptogenesis by regulating nNOS to activate Dexras1.

关键词： CAPON     ISH     differentiation     postnatal     different subcellular    

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脊髓损伤后基因表达和分子调控的系统研究

苏国辉

《工程（英文）》 2020年 第6卷 第4期   页码 389-390 doi: 10.1016/j.eng.2019.12.017

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Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

《医学前沿（英文）》 2007年 第1卷 第2期   页码 177-180 doi: 10.1007/s11684-007-0033-3

摘要： The aim of the present research is to study the mechanism of cervical nerve compression syndrome of the external intervertebral foramen and its differential diagnosis with cervical spondylosis. Diagnostic treatment with muscle relaxant, vasodilator, neurotrophic medicine and celecoxib (COX)-2 inhibitor were performed in 20 patients with cervical nerve compression syndrome of the external intervertebral foramen and 20 patients with cervical spondylosis confirmed by operation. Diagnostic local block therapy was performed additionally in cases showing little effect after diagnostic treatment. All the patients were followed up postoperatively for more than one year. Fifteen cases with cervical nerve compression syndrome of the external intervertebral foramen were healed by the diagnostic treatment. The other five cases had a short-term remission and there was no recurrence after diagnostic local block therapy. Diagnostic treatment led to short-term alleviation of the symptom in 20 cases with cervical spondylosis confirmed by operation, the results of which was far from satisfactory and operation was undertaken finally in all the 20 cases. The etiology of cervical nerve compression syndrome of the external intervertebral foramen lies in the compression of the cervical plexus, brachial plexus and cervical dorsal rami by the tendinous decussating fibers of the scalenus anticus, medius, minimus and the posterior muscles of the neck. Diagnostic treatment was propitious to differentiate cervical nerve compression syndrome of the external intervertebral foramen from cervical spondylosis.

关键词： satisfactory     COX     minimus     operation     compression syndrome    

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超低能导爆索传爆原理及应用的研究

梅群,沈兆武,周听清

《中国工程科学》 2005年 第7卷 第6期   页码 69-72

摘要：

系统地研究了超低能导爆索的传爆原理，结合工程实际需要，拓宽应用范围的研究，为深孔土岩爆破的反向起爆提出一种新型的，安全、可靠、高效的起爆网络。

关键词： 超低能导爆索     反向起爆     炸药压死    

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大鼠脊髓发育过程中时序转录组的发育时间模式和分子网络特征 Article

杨建, 赵莉莉, 易晟, 丁斐, 杨宇民, 刘炎, 王勇军, 刘梅, 薛成斌, 许莲, 龚蕾蕾, 王星辉, 张愉, 于彬, 明国丽, 顾晓松

《工程（英文）》 2021年 第7卷 第11期   页码 1592-1602 doi: 10.1016/j.eng.2021.10.001

摘要：

目前对胎盘哺乳动物脊髓发育的分子网络特征我们知之甚少。这些特征对深入理解与再生相关的重要生物过程和组织工程研究非常必要。现在，借助于从胚胎期到成年期大鼠脊髓的大规模时序转录组分析取得了一些新的进展。研究发现发育早期波动的RNA表达水平反映了脊髓活跃的转录调控并可能启动了脊髓的早期模式发育。脊髓发育过程中由microRNA (miRNA)和转录因子（TF）构成的宏观调控网络在新生期前后存在切换现象（即“镶嵌模型”）。差异可变剪接事件提示了可变剪接可能是郎飞结发育的驱动力之一。我们的研究也支持了脊髓中先天免疫的发育与其内在生长能力之间存在负相关性。发育过程中的一些表观遗传学修饰很可能在不同发育阶段发挥各自的调控功能。G蛋白偶联受体（包括嗅觉受体）可能在发育的轴突生长中发挥多效性作用。该研究为脊髓发育领域提供了有价值的资源，并与越来越多的单细胞数据形成互补，也为开发新的脊髓损伤组织工程策略提供了组学基础。

关键词： 发育     基因表达模式     先天免疫     脊髓     转录组    

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成年哺乳类神经发生在脊髓损伤修复方面的研究进展

杨朝阳, 赵文, 高钰丹, 段红梅, 郝鹏, 郝飞, 李晓光

《工程（英文）》 2021年 第7卷 第12期   页码 1713-1714 doi: 10.1016/j.eng.2021.09.009

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Advances in tissue state recognition in spinal surgery: a review

Hao Qu, Yu Zhao

《医学前沿（英文）》 2021年 第15卷 第4期   页码 575-584 doi: 10.1007/s11684-020-0816-3

摘要： Spinal disease is an important cause of cervical discomfort, low back pain, radiating pain in the limbs, and neurogenic intermittent claudication, and its incidence is increasing annually. From the etiological viewpoint, these symptoms are directly caused by the compression of the spinal cord, nerve roots, and blood vessels and are most effectively treated with surgery. Spinal surgeries are primarily performed using two different techniques: spinal canal decompression and internal fixation. In the past, tactile sensation was the primary method used by surgeons to understand the state of the tissue within the operating area. However, this method has several disadvantages because of its subjectivity. Therefore, it has become the focus of spinal surgery research so as to strengthen the objectivity of tissue state recognition, improve the accuracy of safe area location, and avoid surgical injury to tissues. Aside from traditional imaging methods, surgical sensing techniques based on force, bioelectrical impedance, and other methods have been gradually developed and tested in the clinical setting. This article reviews the progress of different tissue state recognition methods in spinal surgery and summarizes their advantages and disadvantages.

关键词： spinal surgery     tissue state recognition     image     force sensing     bioelectrical impedance    

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 20-29 doi: 10.1007/s11684-014-0371-x

摘要：

Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.

关键词： cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

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第十四届全国脊柱脊髓学术大会 The 14th Congress of Chinese Association of Spinal Cord

会议日期： 2019年08月30日

会议地点： 中国/湖北/武汉

主办单位： 中国康复医学会

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

null

《医学前沿（英文）》 2012年 第6卷 第1期   页码 41-47 doi: 10.1007/s11684-012-0175-9

摘要：

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial source of early stem cells that can be readily manipulated. As the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stem cell therapy. By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible. However, several uncertain aspects, such as the effect of donor selection or culture conditions, long-term therapeutic effects, product consistency, and potential tumorigenicity, are the bottleneck in this clinical therapy. MSCs are predicted to undergo an unprecedented development in clinical treatment when a generally acknowledged criterion emerges. In the current paper, we highlight the application of umbilical cord-derived MSCs in skin therapies based on our previous studies, as well as the achievements of our peers in this field. This paper focuses on the strategies, challenges, and potential of this novel therapy.

关键词： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Influence of steel corrosion on axial and eccentric compression behavior of coral aggregate concrete

《结构与土木工程前沿（英文）》 2021年 第15卷 第6期   页码 1415-1425 doi: 10.1007/s11709-021-0786-9

摘要： To study the behavior of coral aggregate concrete (CAC) column under axial and eccentric compression, the compression behavior of CAC column with different types of steel and initial eccentricity (ei) were tested, and the deformation behavior and ultimate bearing capacity (Nu) were studied. The results showed that as the ei increases, the Nu of CAC column decreases nonlinearly. Besides, the steel corrosion in CAC column is severe, which reduces the steel section and steel strength, and decreases the Nu of CAC column. The durability of CAC structures can be improved by using new organic coated steel. Considering the influence of steel corrosion and interfacial bond deterioration, the calculation models of Nu under axial and eccentric compression were presented.

关键词： coral aggregate concrete column     axial compression     eccentric compression     steel corrosion     calculation model    

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Behavior of dam concrete under biaxial compression-tension and triaxial compression-compression-tension

WANG Huailiang, SONG Yupu

《结构与土木工程前沿（英文）》 2008年 第2卷 第4期   页码 323-328 doi: 10.1007/s11709-008-0043-5

摘要： In order to meet the requirement for nonlinear analysis and design of mass concrete structures, the deformation behavior and strength of three-graded concrete specimens 250 mm × 250 mm × 400 mm with a maximum aggregate size of 80 mm and the corresponding wet-screened concrete specimens 150 mm × 150 mm × 300 mm with a maximum aggregate size of 40 mm were studied experimentally. Specimens subjected to biaxial compression-tension (C-T) and triaxial compression-compression-tension (C-C-T) stress states. Test data indicate that both the deformation and strength of the mass concrete specimens are lower than those of the corresponding wet-screened concrete small specimens, but the initial tangent modulus of the stress-strain curve of the former is greater than that of the latter. Test results show that the wet-screened effect and size effect of the specimens under complex stress states are obvious such that these should be considered in the design of mass concrete structures. In addition, respective failure criteria for mass concrete in principal stress space and octahedron stress space are proposed.

关键词： requirement     wet-screened concrete     compression-tension     maximum aggregate     principal    

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标题 作者 时间 类型 操作

Primary spinal epidural non-Hodgkin’s lymphoma presented with spinal cord compression syndrome

Chunquan CAI MD, PhD, Qingjiang ZHANG BM, Changhong SHEN MD, PhD,

期刊论文

Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

期刊论文

transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinalcord injury

Bin Yu, Xiaosong Gu

期刊论文

Developmental expression of CAPON and Dexras1 in spinal cord of rats

LI Xin, CHENG Chun, CHEN Mengling, GAO Shangfeng, ZHAO Jian, NIU Shuqiong, SHEN Aiguo

期刊论文

脊髓损伤后基因表达和分子调控的系统研究

苏国辉

期刊论文

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

期刊论文

超低能导爆索传爆原理及应用的研究

梅群,沈兆武,周听清

期刊论文

大鼠脊髓发育过程中时序转录组的发育时间模式和分子网络特征

杨建, 赵莉莉, 易晟, 丁斐, 杨宇民, 刘炎, 王勇军, 刘梅, 薛成斌, 许莲, 龚蕾蕾, 王星辉, 张愉, 于彬, 明国丽, 顾晓松

期刊论文

成年哺乳类神经发生在脊髓损伤修复方面的研究进展

杨朝阳, 赵文, 高钰丹, 段红梅, 郝鹏, 郝飞, 李晓光

期刊论文

Advances in tissue state recognition in spinal surgery: a review

Hao Qu, Yu Zhao

期刊论文

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

null

期刊论文

第十四届全国脊柱脊髓学术大会 The 14th Congress of Chinese Association of Spinal Cord

2019年08月30日

会议信息

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

null

期刊论文

Influence of steel corrosion on axial and eccentric compression behavior of coral aggregate concrete

期刊论文

Behavior of dam concrete under biaxial compression-tension and triaxial compression-compression-tension

WANG Huailiang, SONG Yupu

期刊论文